Abstract： Objective： To investigate the effects of Baicalin on inflammatory responses in diabetic cardiomyopathy （DCM） rats by regulating the cGAS-STING signaling pathway. Methods：A total of 48 SD rats were fed a high-fat diet and injected intraperitoneally with streptozotocin （STZ） to establish a DCM model. The rats were randomly divided into four groups：the model group，the Baicalin （120 mg/kg） group，the pc-NC （empty plasmid） group，and the Baicalin and pc-cGAS （120 mg/kg + cGAS overexpression plasmid） group，with 12 rats in each group. Additionally，12 normal rats were fed a normal diet and injected intraperitoneally with an equal dose of citrate buffer solution， serving as the control group. After intervention with Baicalin and plasmids， fasting blood glucose （FBG） levels were measured， heart function was assessed by ultrasound， and left ventricular ejection fraction （EF） and isovolumic relaxation time （IVRT） were compared among the groups； TUNEL staining was used to detect myocardial cell apoptosis； ELISA was employed to measure the levels of creatine kinase-MB （CK-MB） ， lactate dehydrogenase （LDH）， and cardiac troponin I （cTnI） in serum， as well as serum and myocardial tissue levels of inflammatory markers like C-reactive protein（ CRP），interleukin-18（ IL-18），and tumor necrosis factor-α（ TNF-α）； Western blotting was used to detect the expressions of cGAS-STING pathway proteins in myocardial tissue. Results： Compared with those in the control group，the FBG，the myocardial cell apoptosis rate，the levels of CK-MB，LDH， cTnI，CRP，IL-18，and TNF-α in serum，the levels of CRP，IL-18，and TNF-α in myocardial tissue，and the cGAS and STING protein expressions in the model group were significantly increased （P＜0.05）， and IVRT and EF were significantly decreased （P＜0.05）. Compared with those in the model group， the FBG， the myocardial cell apoptosis rate，the levels of CK-MB，LDH，cTnI，CRP，IL-18，and TNF-α in serum，the levels of CRP，IL-18， and TNF- α in myocardial tissue， and the cGAS and STING protein expressions in the Baicalin group were decreased（ P＜0.05），and IVRT and EF were increased（ P＜0.05）；the pc-NC group showed no significant change in these indicators （P＞0.05）. Compared with those in the Baicalin group，the FBG，the myocardial cell apoptosis rate， the levels of CK-MB，LDH，cTnI，CRP，IL-18，and TNF-α in serum，the levels of CRP，IL-18，and TNF-α in myocardial tissue， and the cGAS and STING protein expressions in the Baicalin and pc-cGAS group were increased （P＜0.05），and IVRT and EF were decreased （P＜0.05）. Conclusion：Baicalin can reduce blood glucose levels， inhibit inflammation in DCM rats， and alleviate myocardial cell apoptosis and heart function damage by preventing the activation of the cGAS-STING signaling pathway.