Abstract： Objective： To predict the mechanism of Artemisinin in treating atherosclerosis （AS） by using networks pharmacology and molecular docking. Methods： Using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform （TCMSP）， PubChem database and Swiss Target Prediction database， the effect targets of Artemisinin were obtained， and the AS-related targets were obtained from GeneCards and DisGeNET，and the targets intervening AS by Artemisinin were obtained by gene shine. Using DAVID database，the targets were given enrichment analysis of Gene Ontology （GO） and Kyoto Encyclopedia of Genes and Genomes （KEGG） and visualized by Wei Sheng Xin. The protein-protein interaction （PPI） networks were established by String database and Cytoscape3.10.0 software， and the critical targets were screened out by the cluster analysis and network topology analysis. Then the ingredient of Chinese medicinals-targets-pathways-disease network was established and the critical targets mainly related to disease pathway were selected. The molecular docking of Artemisinin and targets was conducted through AutoDock software and the binding activity was evaluated according to binding energy. Results： A total of 109 targets of Artemisinin， 1 217 AS targets and 35 targets intervening AS by Artemisinin were obtained. The GO enrichement analysis pointed out that the targets intervening AS by Artemisinin mainly participated in the signal transduction，metabolism of xenobiotics，positive regulation of cell proliferation and other biological processes （BP）， related to the cell components （CC） of plasmalemma， cytoplasm and macromolecular compound and involving the molecular functions（ MF） of cholesterol-hydroxylase activity，protein kinase activity and oxidation enzyme activity. The KEGG enrichment analysis suggested that the targets intervening AS by Artemisinin mainly intervened the signaling pathways related to the treatment of AS，including the signaling pathway of mitogen-activated protein kinase （MAPK）， relaxin signaling pathway， cancer signaling pathway， fluid shear stress （FSS）， AS and signaling pathway of reninangiotensin system （Ras）. According to the results of molecular docking，it showed that there was great binding force between Artemisinin and targets of MAPK8， endothelial growth factor receptor （EGFR） and MAPK14. Conclusion： Artemisinin may achieve the curative effect on AS through intervening MAPK signaling pathway， relaxin signaling pathway，cancer signaling pathway，FSS，AS and Ras signaling pathway，and the MAPK8，EGFR and MAPK14 are the core targets for treating AS with Artemisinin.