Abstract：The incidence of shoulder pain in female perimenopausal period is characterized by deficiency in origin and excess in superficiality. The decline of yangming meridian is its prerequisite；the insufficiency of essence blood of the liver and kidney is the disease origin，and the external contraction of pathogenic factors is the disease superficiality. In the syndrome differentiation and treatment of female perimenopausal shoulder pain from the decline of yangming meridian，the treatment principle is to unblock and supplement yangming meridian，taking into account supplementing and boosting the liver and kidney， and in terms of treatment method， the combination of acupuncture and Chinese medicinals is attached great importance.