Abstract： Objective： To observe the clinical effect of the therapy of moxibustion combined with Ziyin Tongluo Prescription on postmenopausal osteoporosis （PMO）. Methods： A total of 110 PMO patients treated in the Zhuhai Hospital of Guangdong Provincial Hispial of Chinese Medicine from October 2020 to December 2021 were selected and divided into the control group and the trial group by random number table method， with 55 cases in each group. The control group was orally treated with Alfacalcidol Soft Capsules and Caltrate Vitamin D Tablets，and the trial group was additionally treated with moxibustion combined with Ziyin Tongluo Prescription based on the treatment of the control group. After continuous treatment for three months， the traditional Chinese medicine （TCM） syndrome scores， bone mineral density， hemorheological indexes [fibrinogen （Fib） ， erythrocyte sedimentation rate （ESR） and hematocrit （HCT）] and bone formation markers [serum propeptide of type Ⅰ procollagen （P Ⅰ NP） and alkaline phosphatase （ALP）] before and after treatment were compared between the two groups， and the clinical effects and safety in the two groups were evaluated. Results：After treatment，the total effective rate was 96.36%（53/55） in the trial group and 83.64%（46/55） in the control group，the difference being significant （P＜0.05）. After treatment，the TCM syndrome scores such as back and waist pain， shin soreness and knee weakness， mental fatigue and limbs weakness in the two groups were decreased when compared with those before treatment （P＜0.05）， and the above scores in the trial group were lower than those in the control group （P＜0.05）. After treatment，the bone density of left femoral neck，right femoral neck bone and lumbar vertebra in the two groups was increased when compared with that before treatment （P＜0.05），and the bone density of left femoral neck，right femoral neck bone and lumbar vertebra in the trial group was higher than that in the control group （P＜0.05）. After treatment，the levels of PⅠNP and ALP in the two groups were increased when compared with those before treatment （P＜0.05），and the levels of PⅠNP and ALP in the trial group were higher than those in the control group （P＜0.05）. After treatment，the levels of Fib，ESR and HCT in both groups were lower than those before treatment （P＜0.05）， and the levels of Fib， ESR and HCT in the trial groups were lower than those in the control group （P＜0.05）. During the treatment， no adverse reactions such as abnormal liver and kidney function and gastrointestinal reaction occurred in the two groups. Conclusion：The therapy of moxibustion combined with Ziyin Tongluo Prescription has a definite effect on postmenopausal osteoporosis， which can increase bone density，promote bone formation and improve the symptoms of back and waist pain.