Abstract： Objective： To observe the clinical effect of heat-sensitive moxibustion combined with the extracorporeal shock wave therapy at acupoints on post-stroke hand spasm. Methods：A total of 45 patients with poststroke hand spasm treated in the First Affiliated Hospital of Henan University of Chinese Medicine and Henan General Hospital from June 2021 to June 2022 were selected and divided into the heat-sensitive group，the shock wave group and the combination group by random number table method， with 15 cases in each group. All the three groups were given routine training of hand function rehabilitation. On this basis， the heat-sensitive moxibustion group was treated with heat-sensitive moxibustion at selected heat-sensitive points near Baxie point and upper Baxie points； the shock wave group was treated with extracorporeal shock wave therapy at Baxie point and upper Baxie points； and the combination group was treated with extracorporeal shock wave therapy at acupoints half a hour after the treatment of heatsensitive moxibustion. Three weeks was a course of treatment，and all the three groups were treated for two courses. The scores of Modified Ashworth Scale （MAS） classification，the root mean square （RMS） of flexor and extensor muscle of fingers， Fugl-Meyer Assessment Scale-Upper Extremity （FMA-UE）， modified Lindmark Scale， and modified Barthel Index （MBI） were compared among the three groups before and after treatment. Results：After treatment，the MAS classification of the three groups was improved when respectively compared with that before treatment， and the MAS classification of the combination group was better than that of the heat-sensitive moxibustion group and the shock wave group， differences being significant （P＜0.05）. The RMS of flexor and extensor muscle of fingers in the three groups were reduced when compared with those before treatment，and the RMS of flexor and extensor muscle of fingers in the combination group were lower than those in the heat-sensitive moxibustion group and the shock wave group， differences being significant （P＜0.05）. The scores of FMA-UE，modified Lindmark Scale and MBI in the three groups were increased when compared with those before treatment，and the scores of FMA-UE，modified Lindmark Scale and MBI in the combination group were higher than those in the heat-sensitive moxibustion group and the shock wave group， differences being significant （P＜0.05）. Conclusion： Heat-sensitive moxibustion combined with the extracorporeal shock wave therapy at acupoints can effectively relieve post-stroke hand spasm，and improve the wrist motor function and the activities of daily living.