Abstract：Objective：To observe the effect of Er'tong Qingyan Jiere Oral Liquid combined with Kaihoujian Spray on children with acute pharyngitis and its influence on immune function. Methods：A total of 86 children with acute pharyngitis treated in Nanyang Central Hospital from March 2022 to March 2023 were selected and divided into the treatment group and the control group according to random number table method， with 43 cases in each group. The treatment group was treated with Er'tong Qingyan Jiere Oral Liquid combined with Kaihoujian Spray， and the control group was treated with Cefixime Granules. After seven days of treatment， the clinical effects， traditional Chinese medicine syndrome scores， immune function （T lymphocyte CD3+ ， CD4+ ， CD8+ and CD4+/CD8+ levels） and the incidence of adverse reactions were compared between the two groups. Results：The total effective rate was 95.35%（41/ 43） in the treatment group and 76.74%（33/43） in the control group，the difference being significant （P＜0.05）. After treatment，the regression time of pharyngeal redness，fever，pharyngeal pain and expectoration in the treatment group was storter than that in the control group （P＜0.05）. After treatment，the scores of primary and secondary syndromes in the two groups were decreased when compared with those before treatment （P＜0.05），and the scores of primary and secondary syndromes in the treatment group were lower than those in the control group （P＜0.05）. After treatment，the levels of serum CD3+ ， CD4+ and CD4+/CD8+ in the two groups were increased when compared with those before treatment （P＜0.05），and the CD8+ levels were decreased when compared with those before treatment （P＜0.05）. The levels of CD3+，CD4+ and CD4+/CD8+ in the treatment group were higher than those in the control group （P＜0.05）， and the CD8+ level was lower than that in the control group （P＜0.05）. The incidence of adverse reactions was 11.63% （5/43） in the treatment group and 6.98% （3/43） in the control group， there being no significant difference between the two groups （P＞0.05）. Conclusion： The therapy of Er'tong Qingyan Jiere Oral Liquid combined with Kaihoujian Spray has a definite therapeutic effect on children with acute pharyngitis，which can effectively relieve the clinical symptoms，accelerate the regression of symptoms and effectively improve the immune function of children.