Abstract: Objective: To observe the clinical effect of Zhangneimo Prescription combined with Drospirenone Ethinylestradiol Tablets on patients with recurrent miscarriage of kidney deficiency and blood stasis type after surgery. Methods:A prospective study was conducted on 82 patients with recurrent miscarriage of kidney deficiency and blood stasis type who underwent dilation and curettage (D&C) in Jiashan Hospital of Traditional Chinese Medicine from January 2018 to December 2022. The patients were divided into the control group (40 cases) and the observation group (42 cases) by random number table method. The control group was treated with Drospirenone Ethinylestradiol Tablets,and the observation group was treated with Zhangneimo Prescription and Drospirenone Ethinylestradiol Tablets. After three courses of treatment,the recovery time,volume and duration of menstruation were observed and recorded after D&C. Before treatment and at the end of the third course of treatment, the traditional Chinese medicine(TCM) syndrome scores were assessed; the endometrial thickness was measured; the endometrial hemodynamic indexes [uterine arterial peak systolic velocity (PSV) and resistance index (RI)] and sex hormone indexes [serum progesterone (P), follicle stimulating hormone (FSH) and estradiol (E2)] were detected. The clinical effects and incidence of adverse reactions were compared between the two groups. Results:After treatment,the TCM syndrome scores in both groups were decreased when compared with those before treatment, the TCM syndrome score in the observation group was lower than that in the control group, differentces being significant (P<0.05). The observation group had earlier postoperative menstruation recovery time than the control group,less menstrual volume,and shorter menstrual duration than the control group,differences being significant (P<0.05). The endometrial thickness in both groups were respectively increased when compared with those before treatment, and the endometrial thickness in the observation group was thicker than that in the control group,differences being significant (P<0.05). The PSV and RI levels in both groups were decreased when compared with those before treatment, and the PSV and RI levels in the observation group were lower than those in the control group,differences being significant (P<0.05). The levels of P, FSH,and E2 in both groups were increased when compared with those before treatment (P<0.05),and the levels of P, FSH,and E2 in the observation group were higher than those in the control group,differences being significant (P< 0.05). The total effective rate was 95.24% (40/42) and the incidence of adverse reactions was 4.76% (2/42) in the observation group, and the total effective rate was 72.50% (29/40) and the incidence of adverse reactions was 22.50%( 9/40) in the control group. There were statistically significant difference in the total effective rate and incidence of adverse reactions between the two groups (P<0.05). Conclusion: The application of Zhangneimo Prescription combined with Drospirenone Ethinylestradiol Tablets has a significant therapeutic effect on patients with recurrent miscarriage of kidney deficiency and blood stasis type after surgery, which can not only alleviate clinical symptoms, promote postoperative menstrual recovery, but also accelerate endometrial growth, improve uterine blood supply and regulate the secretion of sex hormones,and show great safety.