Abstract：Objective：To observe the curative effect of holographic therapy on radial side of the second metacarpal bone on pseudobulbar palsy (PBP) after cerebral infarction. Methods：A total of 112 patients with PBP after cerebral infarction were selected and randomly divided into the control group， the tongue trineedle group， and the treatment group， with 38 cases in each group. One case in the control group and one case in the treatment group failed to follow the treatment plan and fell out，resulting in 38 cases in the tongue tri-needle group，37 cases in the control group，and 37 cases in the treatment group. The control group received conventional treatment for cerebrovascular disease and swallowing dysfunction；the tongue tri-needle group received tongue tri-needle treatment on the basis of the control group； the treatment group received holographic point therapy on the radial side of the second metacarpal bone on the basis of the control group. All the three groups were treated for 14 days. Compared the clinical efficacy of the three groups using the Shi's scoring method and the Kubota Water Swallow Test，and compared the changes in the National Institutes of Health Stroke Scale score (NIHSS)， endothelin-1 (ET-1)， and calcitonin generelated peptide (CGRP) levels before and after treatment in the three groups. Results：After treatment，the NIHSS scores in all the three groups were decreased when compared with those before treatment (P＜ 0.05)， the scores in the tongue tri-needle group and the treatment group were lower than those in the control group at the same time period，differences being significant (P＜0.05). The total effective rate of the Shi's scoring method was 62.16% in the control group， 92.10% in the tongue tri-needle group， and 89.19% in the treatment group； the clinical effects of the Shi's scoring method in the tongue tri-needle group and the treatment group were higher than that in the control group，the difference being significant (P＜0.05). The total effective rate of Kubota Water Swallow Test was 65.57% in the control group，89.47% in the tongue tri-needle group， and 89.19% in the treatment group； the clinical effects of the Kubota Water Swallow Test in the tongue tri-needle group and the treatment group were higher than that in the control group，the difference being significant (P＜0.05). After 14 days of treatment，the serum ET levels in all the three groups were decreased when compared with those before treatment (P＜0.05)，and the levels in the tongue tri-needle group and the treatment group were lower than that in the control group， differences being significant (P＜0.05). After treatment，the serum CGRP levels in all the three groups were increased when compared with those before treatment (P＜0.05)， and the levels in both the tongue trineedle group and the treatment group were higher than that in the control group， differences being significant (P＜0.05). Conclusion：The holographic point therapy on the radial side of the second metacarpal bone can alleviate clinical symptoms， improve cerebral blood flow， enhance quality of life， and promote neurological function recovery.