Abstract：Objective：To observe the curative effect of the combination use of Bushen Sanhan Zhitong Decoction and warm needling therapy on knee osteoarthritis. Methods： A total of 78 patients with knee osteoarthritis of wind-cold-damp blockage type were selected and divided into the observation group and the control group according to the random number table method，with 39 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with Bushen Sanhan Zhitong Decoction combined with warm needling therapy based on the treatment of the control group. Both groups were treated for two months. The clinical effects and incidence of adverse reactions， and the changes of traditional Chinese medicine syndrome scores， scores of Visual Analogue Scale (VAS) of pain， Lequesne Index (Lequesne) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for joint function， and levels of serum tumor necrosis factor- α (TNF- α)， interleukin-6 (IL-6) and interleukin-1β (IL-1β) before and after treatment were compared between the two groups. Results： The total clinical effective rate was 92.31% in the observation group and 74.36% in the control group，the difference being significant (P＜0.05). After treatment，the traditional Chinese medicine syndrome scores of fear of cold and cold limbs， stiffness of joint， soreness and sense of heaviness and weakness in the waist and knees in the two groups were reduced when compared with those before treatment (P＜0.05)， and the above four scores in the observation group were lower than those in the control group (P＜0.05). After treatment，the scores of VAS and WOMAC in the two groups were downregulated when compared with those before treatment， and the Lequesne scores were elevated when compared with those before treatment； the scores of VAS and WOMAC in the observation group were lower than those in the control group， and the Lequesne score was higher than that in the control group (P＜0.05). After treatment，the levels of serum TNF-α，IL-6 and IL-1β in the two groups were decreased when compared with those before treatment， and the above three levels in the observation group were lower than those in the control group (P＜0.05). During the treatment， the incidence of adverse reactions was 12.82% in the observation group and 17.95% in the control group，there being no significance in the difference (P＞0.05). Conclusion： The combination use of Bushen Sanhan Zhitong Decoction and warm needling therapy has a good curative effect on knee osteoarthritis，which can effectively mitigate the clinical symptoms，lessen the pain and improve the knee function with great safety.