Abstract： This paper summarizes the experience of Chief Physician ZHANG Guoliang in treating pulmonary nodules (PN). He believes that the basic pathogenesis of this disease is phlegm-heat accumulation in the lung，the lung failing to diffuse and govern descent，and accumulation of blood stasis and toxin over time. Combined with the density，size，and morphology of the nodule lesions shown on CT scans of the chests，it can be divided into several syndrome types，namely phlegm-heat accumulation in the lung， binding of phlegm and stasis， and phlegm-heat generating toxin. The treatment focuses on diffusing the lung and clearing heat， and resolving phlegm and dissipating masses； syndrome differentiation and treatment is performed with self-formulated Xuanfei Sanjie Decoction as the basic prescription. The syndrome of phlegm-heat accumulation in the lung is treated by clearing the lung， resolving phlegm and dissipating masses， the syndrome of binding of phlegm and stasis by resolving phlegm，dispelling stasis，and dissipating masses，and the syndrome of phlegm-heat generating toxin by resolving phlegm and dissipating masses， and anti-cancer and detoxifying. The treatment always pays attention to protecting the healthy qi.