Abstract： Objective： To observe the clinical effect of spleen-fortifying application combined with transport hub tuina on anorexia of spleen-stomach weakness type and its effect on gastrointestinal motility. Methods：A total of 103 anorexia children of spleen-stomach weakness type were selected as the research subjects，and were divided into the observation group (51 cases) and the control group (52 cases) using a random number table method. Both groups were treated with Oral Zinc Gluconate Solution，and the control group was treated with Jianwei Xiaoshi Tablets. The observation group was treated with spleen-fortifying application combined with transport hub tuina on the basis of the treatment of the control group. Both groups were treated continuously for two weeks. Compared the traditional Chinese medicine (TCM) syndrome scores，D-xylose excretion rates，gastrointestinal motility indexs and the levels of zinc，motilin (MTL)，and gastrin (GAS) in serum before and after treatment in the two groups，and evaluated the clinical effects and incidence of adverse reactions in the two groups. Results：After treatment，the total effective rate was 96.08% in the observation group，which was higher than that of 78.85% in the control group. The TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜ 0.05)，the gastric emptying time and gastric semi-emptying time were shortened (P＜0.05)，and the levels of zinc，MTL，GAS，and D-xylose excretion rates in serum were increased (P＜0.05). The TCM syndrome scores in the observation group were decreased， the gastric emptying time and gastric semi-emptying time were shortened (P＜0.05)， and levels of MTL， GAS， and D-xylose excretion rates were increased when compared with the control group (P＜0.05). There was no significant difference in serum zinc levels between the two groups after treatment (P＞0.05). No adverse reactions occurred during the treatment period in both groups. Conclusion： Spleen-fortifying application combined with transport hub tuina can treat anorexia of spleen-stomach weakness type，regulate gastrointestinal hormones and serum zinc levels in patients，improve gastric emptying function，and have high safety.