Abstract： Objective： To observe the clinical efficacy of navel acupuncture combined with Paroxetine on depression of liver constraint and spleen deficiency type. Methods：A total of 76 cases of patients with depression of liver constraint and spleen deficiency type were divided into the control group and the treatment group according to the random number table method with 38 cases. The control group was treated with Paroxetine， and the treatment group was treated with Paroxetine combined with navel acupuncture. Both groups were treated for six weeks. The scores of the Hamilton Depression Scale-17 score (HAMD-17)， Self-Rating Depression Scale (SDS)， and Pittsburgh Sleep Quality Index (PSQI)， as well as traditional Chinese medicine (TCM) syndrome scores were compared between the two groups before and after treatment. The clinical efficacy and incidence of adverse reactions in the two groups were evaluated. Results：After treatment，the total effective rate of the treatment group was 94.29% ，which was higher than that of 71.43% in the control group (P＜0.05). The scores of HAMD-17，SDS，and PSQI， as well as TCM syndrome scores in the two groups were lower than those before treatment (P＜0.05)，and the scores of HAMD-17，SDS，and PSQI，as well as TCM syndrome scores in the treatment group were lower(P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： The combination of navel acupuncture and Paroxetine in the treatment of depression of liver constraint and spleen deficiency type can effectively alleviate patients' depressive symptoms， improve sleep quality， enhance clinical efficacy， and have high safety.