Abstract： Objective： To observe the clinical efficacy of self-made Zhike Powder combined with ultrasonic drug penetration therapy in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods：A total of 208 cases of patients with AECOPD were randomly divided into the treatment group and the control group (104 cases in each group)， with two patients excluded from each group， leaving 102 patients in each group for the final study. The control group received conventional comprehensive symptomatic treatment， and the treatment group received Zhike Powder combined with ultrasonic drug penetration therapy based on the control group's treatment. After two consecutive treatment courses，the clinical efficacy，traditional Chinese medicine (TCM) syndrome scores，symptom relief time， degree of respiratory difficulty， blood gas indicators， and hospitalization time in the two groups were evaluated. Results：The total effective rate was 94.12% in the treatment group and 85.29% in the control group，with a significant difference (P＜0.05). After treatment，TCM syndrome scores and modified Borg scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the scores in the treatment group were lower than those in the control group (P＜0.05). After treatment， the relief time of wheezing and coughing，the disappearance time of pulmonary rales，and the hospitalization time in the treatment group were all shorter than those in the control group， with a significant difference (P＜0.05). Before treatment，there was no significant difference in levels of after treatment，the levels of partial pressure of oxygen in artery (PaO2) in the two groups were elevated when compared with those before treatment (P＜0.05)， and the levels of partial pressure of carbon dioxide in artery (PaCO2) were reduced when compared with those before treatment (P＜0.05)；the PaO2 level in the treatment group was higher than that in the control group (P＜0.05)，and the PaCO2 level was lower than that in the control group (P＜0.05). Conclusion： The combination of Zhike Powder and ultrasonic drug penetration therapy has a definite therapeutic effect on AECOPD of phlegm-heat accumulating lung type，which can accelerate the relief of clinical symptoms and signs， improve the degree of dyspnea and the blood gas indicators， and shorten the hospitalization time.