Abstract：Objective：To observe the clinical effect of the combination use of Shufeng Jiedu Capsules and triple inhaled therapy on acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods： A total of 90 AECOPD patients were assigned to the observation group and the control group according to the random number table method，with 45 cases in each group. The two groups were given basic treatment after admission； the control group was additionally given triple inhaled therapy of Terbutaline， Budesonide and Acetylcysteine， and the observation group was additionally treated with Shufeng Jiedu Capsules based on the treatment of the control group. After the two groups were treated for seven days， the clinical effects， traditional Chinese medicine (TCM) syndrome scores， and the levels of serum inflammatory factors [interleukin-6 (IL-6)， tumor necrosis factor- α (TNF- α) and hypersensitive C-reactive protein (hs-CRP)] and of lung function indexes [forced expiratory volume in one second (FEV1)， forced vital capacity (FVC) and ratio of FEV1/FVC] were compared between the two groups. Results： The total effective rate was 95.56% in the observation group and 77.78% in the control group， the difference being significant (P＜0.05). After treatment，the TCM syndrome scores in both groups were reduced when compared with those before treatment (P＜0.05)， and the above scores in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of serum hs-CRP， IL-6 and TNF- α in both groups were down-regulated when compared with those before treatment (P＜0.05)，and the above three levels in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of FEV1， FVC and FEV1/FVC in the two groups were up-regulated when compared with those before treatment (P＜0.05)， and the above three levels in the observation group were higher than those in the control group (P＜0.05). Conclusion：The combination use of Shufeng Jiedu Capsules and triple inhaled therapy can enhance the clinical effect on AECOPD， effectively reduce the inflammatory responses and improve the lung function and TCM syndromes.