Abstract：Professor CHENG Honghui proposes the "syndrome-dimension-state" theory based on the theory of "heart stomach correlation" and the three-dimensional homology of "body， qi， and spirit" . He believes that the key pathogenesis of diarrhea-predominant irritable bowel syndrome is liver constraint and spleen deficiency， and restlessness， and the treatment should focus on soothing the liver and resolving constraint，calming the heart and mind，and treating qi and spirit simultaneously. Based on the "syndromedimension- state" theory，good therapeutic effects have been achieved in the differentiation and treatment of diarrhea-predominant irritable bowel syndrome.