Abstract：Objective：To observe the efficacy of Tongluo Huoxue Prescription combined with meridian massage in the treatment of lumbar disc herniation. Methods： A total of 104 patients with lumbar disc herniation were selected and randomly divided into the combination group and the control group ， with 52 cases in each group. The control group received meridian massage，and the combination group received meridian massage combined with Tongluo Huoxue Prescription. The clinical efficacy in the two groups was compared； the changes in traditional Chinese medicine symptom scores， Visual Analogue Scale (VAS) scores of pain， Japanese Orthopaedic Association (JOA) scores， 36-item Short-Form (SF-36) scores， and lower limb nerve conduction velocity before and after treatment were compared between the two groups. Results： The total effective rate of clinical treatment was 94.23% in the combination group and 78.85% in the control group， the difference in clinical efficacy between the two groups being significant (P＜0.05). After treatment， the traditional Chinese medicine symptom scores and VAS scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above scores in the combination group were lower than those in the control group (P＜0.05). After treatment， the JOA scores and SF-36 scores in the two groups were increased when compared with those before treatment (P＜0.05)，and the scores in the combination group were higher than those in the control group (P＜0.05). After treatment，the common peroneal nerve conduction velocity and tibial nerve conduction velocity in the two groups were improved when compared with those before treatment (P＜0.05)，and these velocities in the combination group were faster than those in the control group (P＜0.05). Conclusion：Tongluo Huoxue Prescription combined with meridian massage can effectively relieve lumbar pain symptoms of lumbar disc herniation，and improve lumbar function and quality of life.