Abstract：Objective：To observe the curative effect of Tongqiao Biyan Granules combined with routine western medicine on sinusitis in children and its effect on nasal ventilation function and Sino-Nasal Outcome Test-20 (SNOT-20) scores in children. Methods ： A total of 106 cases of sinusitis children were selected and divided into the study group and the control group according to the random number table method，with 53 cases in each group. The control group was treated with routine western medicine，and the study group received Tongqiao Biyan Granules on the basis of the control group. All treated for four weeks. Evaluated the clinical efficacy of the two groups， compared the traditional Chinese medicine syndrome scores， nasal ventilation function， and SNOT-20 scores before and after treatment， and observed adverse drug reactions. Results： After treatment， the total effective rate was 88.68% in the study group， which was higher than that of 73.58% in the control group (P＜0.05). After treatment， the traditional Chinese medicine syndrome scores in both groups were decreased when compared with those before treatment (P＜0.05)，and the traditional Chinese medicine syndrome scores in the study group were lower than those in the control group (P＜0.05). After treatment，the nasal minimum cross-sectional area (NMCA) and nasal cavity volume (NCV) in both groups were increased when compared with those before treatment，and the nasal airway resistance was decreased when compared with that before treatment (P＜ 0.05)；the NMCA and NCV of the study group were higher than those in the control group，and the nasal airway resistance was lower than that in the control group (P＜0.05). After treatment，the SNOT-20 scores in both groups were decreased when compared with those before treatment (P＜0.05)，and the SNOT-20 scores in the study group were lower than those in the control group (P＜0.05). During the treatment period， there was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： The combination of Tongqiao Biyan Granules and conventional western medicine has a significant therapeutic effect on sinusitis in children without increasing the risk of adverse drug reactions， and can effectively improve nasal ventilation function and quality of life in children.