Abstract：Objective：To observe the curative effect of modified Chaihu Muli Decoction combined with quadruple therapy for helicobacter pylori (Hp) positive chronic superficial gastritis (CSG) with liver-stomach disharmony syndrome. Methods： A total of 82 cases of Hp positive CSG patients with liver-stomach disharmony syndrome were randomly divided into the treatment group and the control group according to the random number table method， with 41 cases in each group. The control group was treated with quadruple therapy， and the treatment group was treated with quadruple therapy combined with modified Chaihu Muli Decoction. Both groups were treated for four weeks. Compared the traditional Chinese medicine (TCM) syndrome scores and levels of interlekin-8 (IL-8)， tumor necrosis factor (TNF) - α， and monocyte chemoattractant protein-1 (MCP-1) in serum between the two groups before and after treatment. Compared the clinical effects，Hp eradication rates，disease recurrence rates，and incidence of adverse reactions between the two groups. Results： After treatment， the Hp eradication rate and total effective rate in the treatment group were 90.24% and 95.12% respectively，higher than those of 68.29% and 75.61% in the control group (P＜0.05). After treatment，the TCM syndrome scores and levels of IL-8， TNF-α，and MCP-1 in serum in both groups were decreased when compared with those before treatment (P＜0.05)， and the TCM syndrome scores and levels of IL-8， TNF- α， and MCP-1 in serum in the treatment group were lower than those in the control group (P＜0.05). After a six-month follow-up， the disease recurrence rate and incidence of adverse reactions in the treatment group were 4.00% and 2.44% respectively，lower than those of 41.18% and 21.95% in the control group (P＜0.05). Conclusion：Modified Chaihu Muli Decoction combined with quadruple therapy can inhibit the inflammatory reactions of the body， improve the Hp eradication rates and clinical effects，reduce the recurrence rates of disease，and have high safety in treating Hp positive CSG with liver-stomach disharmony syndrome.