Abstract： Objective： To observe the clinical effect of modified Lianqiao Jiedu Decoction in treating chronic periodontitis with intense stomach fire syndrome. Methods：The observed cases were 92 cases of chronic periodontitis treated from February 2021 to June 2023. They were randomly divided into the control group and the treatment group，with 46 cases in each group. The control group received routine treatment measures for periodontitis；the treatment group received modified Lianqiao Jiedu Decoction based on the treatment of the control group. Two groups received continuous treatment for four weeks. The scores of the Visual Analogue Scale (VAS) for pain， periodontitis-related indicators， gingival microcirculation-related indicators， the levels of interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in gingival crevicular fluid， and clinical effects were compared between the two groups. Results： After two weeks and four weeks of treatment，the scores of VAS for pain in both groups were decreased compared to those before treatment， and the scores of VAS for pain in the treatment group were lower than those in the control group during the same period， with differences being significant (P＜0.05). After four weeks of treatment， the plaque indexes， gingival indexes， probe depth， and gingival bleeding indexes related to periodontitis in both groups were significantly reduced compared to those before treatment， and the above periodontitisrelated indicators in the treatment group were lower than those in the control group，with differences being significant (P＜0.05). After four weeks of treatment，both groups showed a significant increase in gingival blood flow and blood flow velocity when compared with those before treatment， and the gingival blood flow and blood flow velocity in the treatment group were higher than those in the control group， with differences being significant (P＜0.05). After four weeks of treatment， the levels of IL-6 and PGE2 in the gingival crevicular fluid in the two groups were significantly reduced when compared with those before treatment，and the levels of IL-6 and PGE2 in the gingival crevicular fluid in the treatment group were lower than those in the control group， with differences being significant (P＜0.05). The total effective rate of clinical effects in the treatment group was 93.48%，and 76.09% in the control group，with the difference being significant (P＜0.05). Conclusion：In the treatment of chronic periodontitis with intense stomach fire syndrome， the modified Lianqiao Jiedu Decoction can inhibit inflammatory reactions， effectively improve periodontitis-related indicators and gingival microcirculation，alleviate pain，and enhance clinical efficacy.