Abstract： Objective： To observe the clinical effect of “arrival of qi at the location of disease” acupuncture method at Fengchi (GB 20) point on migraine. Methods：A total of 60 migraine patients were divided into the treatment group and the control group， with 30 cases in each group according to the random number table method. The control group received routine acupuncture treatment at Taiyang (EXHN5) point，Sizhukong (SJ 23) point，Shuaigu (GB 8) point，Fengchi (GB 20) point，Waiguan (SJ 5) point， and Xiaxi (GB 43) piont on both sides. The treatment group selected the same points as the control group， and quickly inserted needles into the Fengchi (GB 20) point based on touching， then slowly adjust the direction and depth of the needle tip to search for qi until the patient feels a sense of soreness and swelling in the head and temporal area，and the remaining points were operated the same as the ones in the control group. Both groups received continuous treatment for four weeks. The Visual Analogue Scale (VAS) scores before and after the first treatment， and the scores of Migraine-Specific Quality of Life Scale (MSQ) and headache symptom before and after four weeks of treatment were compared between the two groups. Evaluated the clinical efficacy of the two groups. Results：After the first treatment，the VAS scores in both groups were decreased when compared with those before treatment (P＜0.05)，and the VAS score in the treatment group was lower than that in the control group (P＜0.05). After four weeks of treatment， the MSQ scores in both groups were decreased when compared with those before treatment (P＜0.05)，there was no significant difference between the two groups (P＞0.05). After four weeks of treatment，the scores of frequency，severity，duration and accompanying symptom and total scores of headache attacks in both groups were decreased when compared with those before treatment (P＜0.05). There was no significant difference in the above scores between the two groups (P＞0.05). The total effective rate was 90.00% in the treatment group，and 86.67% in the control group，there being no significant difference between the two groups (P＞0.05). Conclusion： Both methods can alleviate the pain of migraine patients and improve their quality of life，but the “arrival of qi at the location of disease” acupuncture method at Fengchi (GB 20) point can improve the immediate analgesic effect.