Abstract： Objective： To observe the curative effect of integrated Chinese and western medicine on moderate to severe acne vulgaris of damp-heat accumulation type. Methods：A total of 102 patients with acne vulgaris were selected and divided into western medicine group and the Chinese and western medicine group according to the random number table method，with 51 cases in each group. The western medicine group was treated with irradiation of red and blue light， Roxithromycin Dispersible Tablets and Fusidic Acid Cream， and the Chinese and western medicine group was additionally treated with Pipa Qingfei Decoction based on the treatment of the western medicine group. The two groups were treated for eight weeks. The clinical effects， incidence of adverse reactions and recurrence rates were compared between the two groups；the traditional Chinese medicine (TCM) syndrome scores and the levels of tumor necrosis factor- α (TNF- α)， interleukin-6 (IL-6)， testosterone (T)， follicle-stimulating hormone (FSH)， luteinizing hormone (LH) and estradiol (E2) were compared before and after treatment between the two groups. Results：The total effective rate was 94.12% in the Chinese and western medicine group，higher than that of 80.39% in the western medicine group (P＜0.05). After treatment，the TCM syndrome scores of inflammation and desquamation， papule and pustule， congested cheeks， and itching， swelling and pain in the two groups were decreased (P＜0.05)， and the above scores in the Chinese and western medicine group were lower than those in the western medicine group (P＜0.05). After treatment，the levels of serum TNF- α and IL-6 in the two groups were reduced (P＜0.05)， and the above two levels in the Chinese and western medicine group were lower than those in the western medicine group (P＜0.05). After treatment，the levels of serum FSH，LH and E2 in the two groups were elevated (P＜0.05)，and the levels in the Chinese and western medicine group were higher than those in the western medicine group (P＜ 0.05). The levels of serum T in the two groups were down-regulated (P＜0.05)， and the T level in the Chinese and western medicine group was lower than that in the western medicine group (P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups (P＞0.05). After three months of follow-up，the recurrence rate was 4.17% in the Chinese and western medicine group，lower than that of 21.95% in the western medicine group (P＜0.05). Conclusion： The integrated Chinese and western medicine can effectively improve clinical symptoms of moderate to severe acne vulgaris of damp-heat accumulation type， regulate the levels of serum inflammatory factors and sex hormones，and reduce the recurrence rate with good safety.