Abstract： Objective： To observe the clinical effect of Liqi Xiaozheng Zhitong Prescription combined with antibiotics in the treatment of patients with chronic pelvic inflammatory disease. Methods：The clinical data of 106 patients with chronic pelvic inflammatory disease were given retrospective analysis， and divided into the routine western medicine group and the integrated Chinese and western medicine group according to different treatment methods， with 53 cases in each group. The routine western medicine group was treated with antibiotics， and the integrated Chinese and western medicine group was additionally treated with Liqi Xiaozheng Zhitong Prescription on the basis of the routine western medicine group. Compared the clinical efficacy of the two groups， and compared the traditional Chinese medicine (TCM) syndrome scores， inflammatory factor levels， and hemodynamic indicators before and after treatment between the two groups. Results：The total clinical effective rate was 92.45% in the integrated Chinese and western medicine group， which was higher than that of 77.36% in the routine western medicine group (P＜0.05). After treatment，the scores of TCM syndromes such as low abdominal stabbing pain，lumbosacral distension and pain，and abnormal vaginal discharge were declined in both groups (P＜ 0.05)，and the scores in the integrated Chinese and western medicine group were lower than those in the routine western medicine group (P＜0.05). After treatment， the levels of serum monocyte chemotactic protein-1 (MCP-1)，intercellular adhesion molecule-1 (ICAM-1)，and transforming growth factor-β (TGF- β) were decreased in both groups (P＜0.05)， and the scores in the integrated Chinese and western medicine group were lower than those in the routine western medicine group (P＜0.05). After treatment， the maximum pelvic blood flow velocity (Vmax) and peak systolic blood flow velocity (PSV) levels in both groups were raised (P＜0.05)，and the levels in the integrated Chinese and western medicine group were higher than those in the routine western medicine group (P＜0.05)；the levels of pelvic pulsatility index (PI) and resistance index (RI) were decreased in both groups (P＜0.05)，and the levels above in the integrated Chinese and western medicine group were lower than those in the routine western medicine group (P＜ 0.05). Conclusion：The combination of Liqi Xiaozheng Zhitong Prescription and antibiotics can improve the inflammatory status of patients with chronic pelvic inflammatory disease， regulate hemodynamic levels， improve TCM syndromes，and have good clinical efficacy.