Abstract： Objective： To observe the effect of oral administration of Sanqi Powder combined with autologous blood transfusion on coagulation function，hemorheology and deep vein thrombosis (DVT) in the lower extremity of patients with hip fracture after total hip arthroplasty. Methods： A total of 92 cases of patients with hip fracture were selected and divided into the control group and the observation group according to the random number table method， with 46 cases in each group. Both groups were treated with artificial hip replacement. The control group was treated with autologous blood transfusion during the operation，and the observation group was treated with oral administration of Sanqi Powder on the basis of the control group. The coagulation function indexes [fibrinogen (FIB)，thrombin time (TT)，activated partial thromboplastin time (APTT)， and D-dimer (D-D)］ and hemorheology indexes [whole blood high shear viscosity， plasma viscosity， whole blood low shear viscosity， and erythrocyte sedimentation rate (ESR)] before and after treatment and the incidence of complications during treatment were compared between the two groups. Results：During the treatment period，three cases in the control group and four cases in the observation group were eliminated， and finally 43 cases in the control group and 42 cases in the observation group were completed. After treatment，FIB，D-D，ESR，whole blood high shear viscosity， plasma viscosity and whole blood low shear viscosity levels were reduced in the two groups compared with before treatment (P＜0.05)，and TT，APTT all was prolonged (P＜0.05)，FIB，D-D，ESR and whole blood high shear viscosity， plasma viscosity， whole blood low shear viscosity levels in observation group were lower than those in control group (P＜0.05)，TT，APTT was longer than that in control group (P＜0.05). The incidence of DVT in the lower extremity in the observation group was lower than that in the control group (P＜0.05). Conclusion： The oral administration of Sanqi Powder combined with autologous blood transfusion can effectively improve the coagulation function and hemorheology indexes of patients with hip fracture after total hip arthroplasty，and reduce the incidence of postoperative DVT in the lower extremity.