Abstract： Objective： To observe the clinical effect of Qingxin Xiegan Anshen Prescription combined with Paroxetine on generalized anxiety disorder (GAD) complicated with insomnia of effulgent heart-liver fire type. Methods： A total of 128 cases of patients with GAD complicated with insomnia were selected and divided into the Anshen group and the control group with 64 cases respectively according to random number table method. The control group was given the oral administration of Paroxetine Hydrochloride Tablets，and the Anshen group was additionally treated with Qingxin Xiegan Anshen Prescription based on the treatment of the control group. Both groups were treated for eight weeks. The clinical effects in the two groups were evaluated； traditional Chinese medicine (TCM) syndrome scores， Pittsburgh Sleep Quality Index (PSQI) scores，Dysfunctional Beliefs and Attitudes about Sleep Scale-Chinese Version (DBAS-CV) scores，Selfrating Depression Scale (SDS) scores， and Generalized Anxiety Disorder-7 (GAD-7) scores in the two groups were compared before and after treatment. The levels of noradrenaline (NE)，5-hydroxytryptamine (5-HT) and dopamine (DA) in serum in the two groups were detected；the occurrence of adverse reactions in the two groups were recorded. Results： After treatment， the total effective rate was 95.31% in the Anshen group，higher than that of 84.38% in the control group (P＜0.05). After treatment，TCM syndrome scores，PSQI scores，SDS scores and GAD-7 scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above scores in the Anshen group were lower than those in the control group (P＜0.05). After treatment， DBAS-CV scores in the two groups were increased when compared with those before treatment (P＜0.05)，and the DBAS-CV score in the Anshen group was higher than that in the control group (P＜0.05). After treatment， the levels of NE and DA in serum in the two groups were declined when compared with those before treatment，and 5-HT levels were elevated when compared with those before treatment (P＜0.05)； the levels of NE and DA in serum in the Anshen group were lower than those in the control group，and the level of serum 5-HT was higher than that in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： Qingxin Xiegan Anshen Prescription combined with Paroxetine has a good effect on the treatment of GAD complicated with insomnia of effulgent heart-liver fire type， which can effectively reduce the anxiety of patients and improve sleep status，with fewer adverse reactions.