Abstract： Objective： This study aimed to evaluate the effectiveness of modified Wuhu Decoction in conjunction with Azithromycin sequential therapy for treating mycoplasma pneumoniae pneumonia in children differentiated as phlegm-heat obstructing the lung type. Methods： A total of 80 children with mycoplasma pneumoniae of phlegm-heat obstruction the lung tpye were selected and randomly divided into the control group or the observation group， with 40 participants in each group. Both groups received Azithromycin sequential therapy， while the observation group also received modified Wuhu Decoction. The treatment lasted for two weeks. The following indexes were compared between the two groups before and after treatment： traditional Chinese medicine (TCM) syndrome score， Pro-inflammatory markers[interleukin-6 (IL-6) and C-reactive protein (CRP)]， T lymphocyte subpopulation indicators (CD4+ T lymphocyte， CD8+ T lymphocyte， and the CD4+ /CD8+ ratio)， and immune factors [immunoglobulin G (IgG)， immunoglobulin A (IgA)， and immunoglobulin M (IgM)]. The clinical effects in the two gruops were compared. Results： After two-week treatment， the total effective rate in the observation group was higher than that in the control group (P＜0.05). The TCM syndrome score in both groups were lower when compared with those before treatment (P＜0.05). The TCM syndrome scores in the observation group was lower than that in the control group (P＜0.05). The levels of IL-6 and CRP in both groups were decreased when compared with those before treatment (P＜0.05). The levels of IL-6 and CRP in the observation group were lower than those in the control group (P＜0.05). The CD4+ T lymphocyte levels and CD4+/CD8+ ratios in both groups were increased when compared with those before treatment (P＜0.05). The CD8+ T lymphocyte level in the observation group was decreased when compared with that before treatment (P＜0.05). The CD4+ T lymphocyte level and CD4+/CD8+ ratios in the observation group were higher than those in the control group， while CD8+ T lymphocyte level in the observation group was lower than that in the control group， differences being significant(P＜0.05). The levels of IgG and IgA in the observation group were increased when compared with those before treatment， while the level of IgM was decreased when compared with that before treatment (P＜0.05). The levels of IgG and IgA in the observation group were higher than those in the control group ， while the level of IgM in the observation group was lower than that in the control group ， differences being significant(P＜0.05). Conclusion： The combination of modified Wuhu Decoction and Azithromycin sequential therapy shows significant therapeutic benefits for mycoplasma pneumoniae pneumonia in children of phlegm-heat obstructing the lung type， effectively alleviating symptoms， reducing inflammation，and boosting immunity.