Abstract：Objective：To observe the clinical effect of the combination use of modified Baihe Dihuang Decoction and Duloxetine Hydrochloride Enteric Capsules on depression. Methods： A total of 82 patients with depression were selected and divided into the combination group and the western medicine group according to the random number table method，with 41 cases in each group. The western medicine group was treated with Duloxetine Hydrochloride Enteric Capsules， and the combination group was additionally treated with modified Baihe Dihuang Decoction based on the treatment of the western medicine group. The clinical effects，and the changes of scores of Hamilton Depression Scale (HAMD)，Self-Rating Depression Scale (SDS)and 36-Item Short Form Health Survey (SF-36)，traditional Chinese medicine syndrome scores， and levels of serum cortisol (CORT)，malondialdehyde (MDA) and superoxide dismutase (SOD) before and after treatment were compared between the two groups. Results：The total effective rate was 92.68% in the combination group and 70.73% in the western medicine group， the difference being significant (P＜ 0.05). After four and eight weeks of treatment， the scores of HAMD and SDS in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above two scores in the combination group were lower than those in the western medication group at the same time (P＜0.05). After treatment，the traditional Chinese medicine syndrome scores of apathy，chest tightness and shortness of breath， taciturnity and depression in the two groups were lower than those before treatment (P＜0.05)， and the above four scores in the combination group were lower than those in the western medicine group (P＜0.05). After treatment， the levels of serum CORT and MDA in the two groups were reduced when compared with those before treatment (P＜0.05)， and the levels of serum SOD were elevated when compared with those before treatment (P＜0.05)；the levels of serum CORT and MDA in the combination group were lower than those in the western medicine group (P＜0.05)， and the serum SOD level was higher than that in the western medicine group (P＜0.05). After treatment，the SF-36 scores of bodily pain， physical functioning， role-physical， psychological well-being， role-emotional， mental health， vitality， social functioning and general health in the two groups were up-regulated when compared with those before treatment (P＜0.05)，and the above nine scores in the combination group were higher than those in the western medicine group (P＜0.05). There was no significant difference being found in the incidence of complications between the two groups(P＞0.05). Conclusion： The combination use of modified Baihe Dihuang Decoction and Duloxetine Hydrochloride Enteric Capsules has a good clinical effect on depression， which can relieve depression symptoms and clinical stress responses，and improve the quality of life with great safety.