Abstract： Objective： To observe the clinical effect of catgut embedment in acupoint assisting quadruple therapy on chronic atrophic gastritis (CAG) complicated with helicobacter pylori (Hp) infection of spleen-stomach weakness type. Methods： A total of 112 cases of CAG complicated with Hp infection patients of spleen-stomach weakness type were selected and divided into the control group (treated with quadruple therapy) and the observation group (treated with catgut embedment in acupoint assisting quadruple therapy)，with 56 cases in each group，using a random number table method. After treatment， both groups were followed up for five months. Compared with the clinical efficacy，gastric mucosal function indicators [gastrin 17 (G-17) and pepsinogenⅠ(PGⅠ)，36-Item Short Form Health Survey (SF-36) scores， traditional Chinese medicine (TCM) syndrome scores，pathological scores，incidence of adverse reactions， and recurrence rates between the two groups. Results： The total effective rate was 96.43% in the observation group， which was higher than that of 80.36% in the control group (P＜0.05). Three months after treatment，the levels of G-17 and PGⅠ in serum in both groups were increased when compared with those before treatment (P＜0.05)，and the levels of the above two indicators in the observation group were higher than those in the control group (P＜0.05). One month and three months after treatment，the SF-36 scores in both groups were increased when compared to those before treatment (P＜0.05)，and the SF-36 score in the observation group was higher than that in the control group during the same period (P＜0.05). Three months after treatment， the TCM syndrome scores in the two groups were decreased when compared to those before treatment (P＜0.05)，and the TCM syndrome score in the observation group was lower than that in the control group (P＜0.05). Five months after treatment，the pathological scores in both groups were declined when compared to those before treatment (P＜0.05)， and the pathological score in the observation group was lower than that in the control group (P＜0.05). The incidence of adverse reactions was 8.93% in the observation group，and 3.57% in the control group，there being no significant difference (P＞0.05). Five months after treatment， the recurrence rate was 1.85% in the observation group， lower than that of 15.56% in the control group (P＜0.05). Conclusion： Catgut embedment in acupoint assisting quadruple therapy can alleviate clinical symptoms， improve gastric mucosal function， improve quality of life，and reduce recurrence rates in patients with CAG accompanied by Hp infection with spleen-stomach weakness type，which is safe.