Abstract： Objective： To observe the clinical efficacy of cluster needling of scalp point long needle retention method on mild cognitive dysfunction after ischemic stroke. Methods： Using a random number table method， a total of 160 cases of patients with mild cognitive dysfunction after ischemic stroke were divided into the observation group and the control group， with 80 cases in each group. Two groups were given conventional western medicines and cognitive function training treatment. The control group was treated with ordinary scalp acupuncture therapy， while the observation group was treated with cluster needling at scalp acupoints with long needle retention therapy. Both groups were treated continuously for six weeks.Compared the scores of the Vascular Dementia Assessment Scale- Cognitive Subscale (VADAScog)， Montreal Cognitive Assessment Scale (MoCA)，Mini-Mental State Examination (MMSE)，Activities of Daily Living Scale (ADL)， Global Decline Scale (GDS)， Scale for the Differentiation of Syndromes of Vascular Dementia (SDSVD)，and levels of plasma dopamine (DA)，norepinephrine (NE)，serotonin (5-HT)， and calcitonin gene-related peptide (CGRP) before and after treatment between the two groups. Results： The total effective rate was 95.00% in the observation group，which was higher than that of 81.25% in the control group (P＜0.05). After treatment，the scores of MMSE，MoCA，and ADL，as well as the levels of plasma DA，NE，5-HT，and CGRP in both groups were higher than those before treatment (P＜0.05). The scores of VADAS-cog， GDS， and SDSVD were decreased (P＜0.05)； the scores of MMSE， MoCA， ADL，and levels of plasma DA，NE，5-HT，and CGRP in the observation group were higher than those in the control group after treatment (P＜0.05)，and the scores of VADAS-cog，GDS，and SDSVD were lower than those in the control group (P＜0.05). Conclusion：Cluster needling of scalp point long needle retention method has a definite therapeutic effect in treating mild cognitive dysfunction after ischemic stroke，which can regulate the level of neurotransmitter，improve the cognitive function and improve the quality of life in patients.