Abstract： Objective： To observe the clinical effect of Shenqi Qingdu Decoction on maintenance hemodialysis (MHD) patients and its effect on nutritional status and hypercoagulable state. Methods：A total of 117 MHD patients were divided into the control group (59 cases) and the observation group (58 cases) using a random number table method. The control group was given routine MHD and basic treatment，and the observation group was treated with Shenqi Qingdu Decoction in addition to the treatment in the control group. Both groups were treated for six months. The clinical effects and adverse reactions were compared between the two groups. The levels of traditional Chinese medicine (TCM) syndrome scores， nutritional status， and blood hypercoagulability indicators [whole blood low shear viscosity， whole blood high shear viscosity， plasma viscosity， and plasma fibrinogen (Fib)， D-dimer (D-D)， and activated partial thromboplastin time (APTT)] were compared before and after treatment. Results：After treatment，the total effective rate was 98.28% in the observation group， and 83.05% in the control group， and there was significant difference between the two groups (P＜0.05). After treatment， the TCM syndrome scores of abdominal distension and fullness，fatigue and lack of strength，and waist and knee soreness，as well as the total scores in both groups were decreased when compared with those before treatment (P＜0.05)， and the observation group had lower scores than the control group in all the above aspects (P＜0.05). After treatment，the proportion of patients with good nutrition in the two groups were increased when compared with those before treatment (P＜0.05)，and the proportion of patients in the observation group was higher than that in the control group (P＜0.05)；the proportion of severe malnutrition patients in both groups were declined when compared with those before treatment (P＜0.05)， and the proportion in the observation group was lower than that in the control group (P＜0.05). After treatment， the whole blood high shear viscosity，whole blood low shear viscosity，plasma viscosity，and plasma APTT，Fib，D-D levels in both groups were decreased when compared with those before treatment (P＜0.05)；the above indicators in the observation group were lower than those in the control group (P＜0.05). During the treatment period，the incidence of adverse reactions was 6.90% in the observation group， and 10.17% in the control group， there was no significant difference between the two groups (P＞0.05). Conclusion：The treatment of MHD patients with Shenqi Qingdu Decoction can improve clinical effects，effectively improve TCM syndromes， blood hypercoagulability，and nutritional status.