Abstract：Objective：To observe the clinical effect of Shengxian Decoction combined with nebulization inhalation for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with sinking of pectoral qi syndrome. Methods： A total of 120 cases of patients with AECOPD with sinking of pectoral qi syndrome were divided into the observation group and the control group by random number table method， with 60 cases in each group. The control group was treated with nebulized inhalation of Salbutamol Sulfate， and the observation group was additionally treated with Shengxian Decoction based on the control group. After two weeks of continuous treatment，clinical effects and traditional Chinese medicine (TCM) syndrome scores were evaluated； the changes in lung function [forced expiratory volume in one second (FEV1)， forced vital capacity (FVC)， the percentage of FEV1 to the expected value (FEV1%)， and FEV1/FVC]， inflammatory factors [procalcitonin (PCT) and C-reactive protein (CRP)]， and oxidative stress indicators [malondialdehyde (MDA) and superoxide dismutase (SOD)] levels before and after treatment were observed. Results： The total effective rate was 95.00% in the observation group and 81.67% in the control group， and the difference between the two groups was significant (P＜0.05). After treatment，the TCM syndrome scores in the two groups were reduced when compared with those before treatment (P＜0.05)， and the scores in the observation group were lower than those in the control group (P＜0.05). After treatment， FEV1， FVC， FEV1%， and FEV1/FVC in the two groups were increaed when compared with those before treatment (P＜0.05)， and the above indicators in the observation group were higher than those in the control group (P＜0.05). After treatment， the levels of PCT and CRP in serum in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above two indicators in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of MDA in the two groups were declined when compared with those before treatment (P＜0.05)， and the MDA level in the observation group was lower than that in the control group (P＜0.05)； SOD levels in the two groups were increased when compared with those before treatment (P＜0.05)， and the SOD level in the observation group was higher than that in the control group (P＜0.05). Conclusion： Shengxian Decoction combined with nebulization inhalation has a definite effect on the treatment of AECOPD with sinking of pectoral qi syndrome， which plays a positive role in alleviating TCM syndrome， improving lung function， reducing inflammatory responses，and regulating oxidative stress responses in patients.