Abstract：Objective：To observe the effect of Bushen Tiansui Yizhi Prescription combined with routine therapy for Alzheimer's disease (AD) of liver-kidney deficiency type. Methods： A total of 100 cases of patients with mild to moderate AD of liver-kidney deficiency type were randomly divided into the combination group and the control group， with 50 cases in each group. Both groups were treated with routine therapy like Donepezil Hydrochloride Tablets and cognitive function training， and the combination group was additionally treated with Bushen Tiansui Yizhi Prescription. Both groups were treated for eight weeks. Traditional Chinese medicine (TCM) syndrome scores， cognitive function [Mini-mental State Examination (MMSE) scores， Alzheimer's Disease Assessment Scale-Cognitive Section (ADAS-Cog) scores]， and the scores of behavioral and psychological symptoms [Neuropsychiatric Inventory (NPI) scores， rating scale of the behavioral pathology in Alzheimer's disease (BEHAVE-AD) scores] were evaluated before and after treatment； the levels of inflammatory factors [(interleukin-6 (IL-6)， tumor necrosis factor α (TNF- α)， interleukin-1β (IL-1β)] were detected. The clinical effects in the two groups were compared. Results：After eight weeks of treatment，the total effective rate in the combination group was higher than that in the control group (P＜0.05). The TCM syndrome score in the combination group was decreased when compared with that before treatment (P＜0.05)，and the score was lower than that in the control group after treatment (P＜0.05). The MMSE scores in the two groups were increased when compared with those before treatment (P＜0.05)， and MMSE score in the combination group was higher than that in the control group (P＜0.05). The scores of ADAS-Cog，NPI and BEHAVE-AD in the two groups were decreased when compared with those before treatment (P＜0.05)， and the three scores in the combination group were lower than those in the control group (P＜0.05). The levels of IL-6， TNF- α and IL-1β in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of IL-6，TNF-α and IL-1β in the combination group were lower than those in the control group (P＜ 0.05). Conclusion： The application of Bushen Tiansui Yizhi Prescription combined with routine therapy for patients with mild to moderate AD of liver-kidney deficiency has a significant curative effect， which can effectively alleviate inflammatory responses， improve the behavioral and psychological symptoms of patients，and enhance their cognitive function.