Abstract： Objective： To observe the clinical effect of Chinese medicine pillow in the treatment of insomnia in maintenance hemodialysis patients. Methods： A total of 70 insomnia patients undergoing maintenance hemodialysis were selected and divided into the treatment group and the control group according to random number table method， with 35 cases in each group. Kidney integration and regular hemodialysis treatment were given to both groups. The treatment group was treated with Chinese medicine pillow and the control group was treated with comfort pillow. The course of treatment of both groups was three months. The clinical efficacy and scores of Pittsburgh Sleep Quality Index (PSQI) and Hamilton Anxiety Scale (HAMA) and Traditional Chinese medicine (TCM) syndrome scores before and after treatment were compared between the two groups. Results：After treatment，the total effective rate was 91.43% in the treatment group，higher than that of 62.86% in the control group (P＜0.05). After treatment，HAMA score， TCM syndrome scores， and PSQI dimension (sleep quality， time to fall alseep， sleep duration， sleep efficiency，sleep disorder，daytime dysfunction) score and total score of the two groups were lower than before treatment， and HAMA score ， TCM syndrome scores， and PSQI score of the treatment group were lower than that of the control group (P＜0.05). Conclusion： Chinese medicine pillows adjuvant treatment can have a significant therapeutic effect on insomnia patients complicated with maintenance hemodialysis，which can effectively improve their sleep and quality of life.