Abstract： Objective： To observe the curative effect of Jianpi Hewei Prescription combined with moxibustion on ginger for chronic atrophic gastritis (CAG) of deficiency-cold of the spleen and stomach type. Methods：A total of 96 cases of patients with CAG of deficiency-cold of the spleen and stomach type were selected and randomly divided into the combination group and the control group， with 48 cases in each group， using a random number table method. The control group was treated with conventional modern medicine， and the combination group was treated with Jianpi Hewei Prescription combined with moxibustion on ginger on the basis of the control group. After eight weeks of continuous treatment， the clinical effects and safety of the two groups were compared， and the changes in traditional Chinese medicine syndrome scores， gastroscopy histological scores， and gastric motility index values were compared before and after treatment in both groups. Results：The total clinical effective rate was 93.75% in the combination group，and 79.17% in the control group，the difference being significant (P＜0.05). After treatment，the traditional Chinese medicine symptom scores of epigastric pain or fullness，liking to press and warm， feeling tired and weak， having limited appetite， shortness of breath and lazy speech， and loose stools in the two groups were declined when compared with those before treatment (P＜0.05)；the above six traditional Chinese medicine symptom scores in the combination group were all lower than those in the control group (P＜0.05). After treatment， the histological scores of intestinal metaplasia， glandular atrophy， dysplasia， disease activity， and chronic inflammation in both groups were decreased when compared with those before treatment (P＜0.05)， and the combination group had lower scores than the control group (P＜0.05). After treatment，the frequency and amplitude of gastric contraction in both groups were raised when compared with those before treatment (P＜0.05)， and the frequency and amplitude of gastric contraction in the combination group were higher than those in the control group (P＜0.05). During the treatment period，there was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： The combination of Jianpi Hewei Prescription combined with moxibustion on ginger has a higher therapeutic effect on CAG of deficiency-cold of the spleen and stomach type，which can regulate abnormal gastric mucosal tissue and improve gastrointestinal motility，with high safety.