Abstract：Objective：To observe the curative effect of the combination use of pricking blood at Zhiwu Point and modified Simiao Decoction on stress injury in stages Ⅲand Ⅳ and its effect on growth factor in granulation tissue. Methods：A total of 120 patients with stress injury in stages ⅢandⅣ were selected and divided into the control group and the observation group according to the random number table methods， with 60 cases in each group. The control group was given routine treatment， and the observation group was additionally treated with pricking blood at Zhiwu Point combined with modified Simiao Decoction based on the treatment of the control group. The clinical effects，incidence of adverse reactions，and the changes in scores of Bates-Jensen Wound Assessment Tool (BWAT)，occurrence time of granulation tissue，time of granulation covering the wound and growth factors in granulation tissue [transforming growth factor- β1 (TGF- β1)， matrix metalloprotein-9 (MMP-9) and vascular endothelial growth factor (VEGF)] before and after treatment were compared between the two groups. Results： The total clinical effective rate was 98.33% in the observation group and 86.67% in the control group， the difference being significant (P＜ 0.05). After treatment， the BWAT scores in the two groups were reduced when compared with those before treatment (P＜0.05)， and the BWAT score in the observation group was lower than that in the control group (P＜0.05). The occurrence time of granulation tissue and the time of granulation covering the wound in the observation group were respectively shorter than those in the control group， differences being significant (P＜0.05). After treatment， the indexes of TGF- β1 and VEGF in the two groups were elevated when compared with those before treatment (P＜0.05)， and the MMP-9 indexes were downregulated when compared with those before treatment (P＜0.05)；the indexes of TGF-β1 and VEGF in the observation group were higher than those in the control group (P＜0.05)，and the MMP-9 index was lower than that in the control group (P＜0.05). During the treatment， no obvious adverse reactions occurred in both groups. Conclusion： The combination use of pricking blood at Zhiwu Point and modified Simiao Decoction has a great curative effect on pressure injury in stages Ⅲ and Ⅳ ， which can shorten the occurrence time of granulation tissue and the time of granulation covering the wound，promote the growth of granulation tissue，and is conducive to rapid recovery.