Abstract：Objective：To observe the curative effect of Jianpi Xiaoji Prescription combined with tuina on children indigestion with spleen deficiency and accumulation syndrome and its effect on traditional Chinese medicine syndrome scores. Methods： A total of 96 children with indigestion with spleen deficiency and accumulation syndrome were selected and divided into the combination group and the control group according to the random number table method，with 48 cases in each group. The control group was treated with western medicine， and the combination group was additionally treated with Jianpi Xiaoji Prescription combined with tuina based on the treatment of the control group. Both groups were treated for 4 weeks. The clinical effects and the incidence of adverse reactions were compared between the two groups； the changes of traditional Chinese medicine syndrome scores， values of gastric emptying function related indexes and gastrin (GAS) levels before and after treatment were compared between the two groups. Results： The total effective rate was 95.83% in the combination group and 83.33% in the control group， the difference being significant (P＜0.05). After 4 weeks of treatment， the scores of traditional Chinese medicine syndromes like withered yellow complexion，poor appetite，feeling full after eating only a little， nausea and vomiting，and thin and unformed stool in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above five traditional Chinese medicine syndrome scores in the combination group were lower than those in the control group (P＜0.05). After 4 weeks of treatment，the maximum satiety stomach volume and gastric half-emptying time in the two groups were reduced and shortened when compared with those before treatment (P ＜ 0.05) ， and the gastric emptying rates at 0.5 hour，1 hour and 2 hours after meals were increased when compared with those before treatment (P＜ 0.05)；the gastric half-emptying time in the combination group was shorter than that in the control group (P＜0.05)，and the gastric emptying rates at 0.5 hour，1 hour and 2 hours after meal were higher than those in the control group (P＜0.05). After 4 weeks of treatment，the serum GAS levels in the two groups were elevated when compared with those before treatment (P＜0.05)， and the serum GAS level in the combination group was higher than that in the control group (P＜0.05). The incidence of adverse reactions was 6.25% in the combination group and 10.42% in the control group，there being no significant difference in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： Jianpi Xiaoji Prescription combined with tuina for children indigestion can improve the clinical effect，relieve clinical symptoms and enhance gastrointestinal motility and gastric emptying function，with high safety.