Abstract： Objective： To observe the clinical effect of Wenyang Cuyun Prescription assisting western medicine on patients with polycystic ovary infertility. Methods： The clinical data of 100 patients with polycystic ovary infertility were retrospectively analyzed，and they were divided into the control group and the observation group according to the clinical treatment method，with 50 cases in each group. The control group was treated with Clomifene， and the observation group was additionally treated with Wenyang Cuyun Prescription based on the treatment of the control group. Sex hormone levels， ovarian volume， follicle number， endometrial thickness， and ovarian arterial blood flow before and after treatment were compared between the two groups，and adverse reactions and pregnancy status were compared between the two groups. Results： After treatment， the levels of luteinizing hormone in the two groups were decreased (P＜0.05)，and the level in the observation group was lower than that in the control group (P＜ 0.05)；the levels of estradiol and follicle stimulating hormone in the two groups were increased (P＜0.05)， and the levels in the observation group were higher than those in the control group (P＜0.05). After treatment，the ovarian volume in the two groups were reduced (P＜0.05)，and the ovarian volume in the observation group was lower than that in the control group (P＜0.05). The number of follicles in the two groups were decreased (P＜0.05)， and the number in the observation group was smaller than that in the control group (P＜0.05). The endometrial thickness in the two groups was increased (P＜0.05)， and the endometrial thickness in the observation group was thicker than that in the control group (P＜0.05). After treatment，the pulsation index (PI) and resistance index (RI) in ovarian artery blood flow were decreased (P＜ 0.05)，and the above indexes in the observation group were lower than those in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). The clinical pregnancy rate was 64.00% in the observation group，which was higher than that of 36.00% in the control group (P＜0.05). Conclusion： Wenyang Cuyun Prescription assisting western medicine for polycystic ovary infertility can improve sex hormone levels， endometrial thickness， ovarian artery blood flow and pregnancy，and has certain safety.