苏芪定喘协定方联合中医肺康复治疗慢性阻塞性肺疾病稳定期临床研究
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R563

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安徽中医药大学临床科研项目(2021LCHB02);安徽省中医药传承创新科研项目(2022CCYB17);安徽省卫生健康科研项目(AHWJ2022b115);淮北市科技局项目(2018GY02)


Clinical Study on Suqi Dingchuan Prescription Combined with Chinese Medicine Lung Rehabilitation for Chronic Obstructive Pulmonary Disease in Stable Phase
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    摘要:

    目的:观察苏芪定喘协定方联合中医肺康复治疗慢性阻塞性肺疾病(COPD) 稳定期的临床疗效。 方法:选取稳定期COPD患者90例,按随机数字表法分为观察组和对照组各45例。对照组给予常规治疗,观 察组在对照组基础上加服苏芪定喘协定方,并配合中医特色肺康复技术。评价2组临床疗效,比较2组中医证 候积分,检测患者治疗前后第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC、超敏C-反应蛋 白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6) 及白细胞介素-8(IL-8) 水平。结果:治 疗后,观察组总有效率为95.56%,高于对照组82.22% (P<0.05)。治疗后,2 组中医证候积分较治疗前降 低(P<0.05),且观察组中医证候积分低于对照组(P<0.05)。治疗后,2组FEV1、FVC以及FEV1/FVC值较治 疗前升高(P<0.05),且观察组FEV1、FVC 以及FEV1/FVC 值高于对照组(P<0.05)。治疗后,2 组IL-6、 IL-8、TNF-α、hs-CRP水平较治疗前降低(P<0.05),且观察组IL-6、IL-8、TNF-α、hs-CRP水平低于对照 组(P<0.05)。结论:苏芪定喘协定方联合中医肺康复治疗COPD稳定期可提高临床疗效,改善患者肺功能及 减轻炎症反应。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Suqi Dingchuan Prescription combined with Chinese medicine lung rehabilitation on chronic obstructive pulmonary disease (COPD) in stable phase. Methods: A total of 90 cases of COPD patients in stable phase were selected and divided into the observation group and the control group according to the random number table method,with 45 cases in each group. The control group was treated with conventional therapy, and the observation group was additionally treated with Suqi Dingchuan Prescription and Chinese medicine lung rehabilitation based on the treatment of the control group. Clinical effects were evaluated in the two groups. Forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC, hypersensitive C-reactive protein (hs- CRP), tumor necrosis factor- α (TNF- α), interleukin-6 (IL-6), and interleukin-8 (IL-8) levels were detected before and after treatment. Results:After treatment,the total effective rate was 95.56% in the observation group,higher than that of 82.22% in the control group (P<0.05). After treatment,traditional Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment (P<0.05),and traditional Chinese medicine syndrome score in the observation group was lower than that in the control group (P<0.05). After treatment, the values of FEV1, FVC, and FEV1/FVC in the two groups were increased when compared with those before treatment (P<0.05),and the values of FEV1, FVC,and FEV1/FVC in the observation group were higher than those in the control group (P<0.05). After treatment, the levels of IL-6, IL-8, TNF- α, and hs-CRP in the two groups were declined when compared with those before treatment (P<0.05),and the levels of IL-6,IL-8,TNF- α,and hs-CRP in the observation group were lower than those in the control group (P<0.05). Conclusion: Suqi Dingchuan Prescription combined with Chinese medicine lung rehabilitation for COPD in stable phase can improve clinical effects and lung function of patients,and relieve inflammatory responses.

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汪严,郑彩霞,赵秋梅,于盼.苏芪定喘协定方联合中医肺康复治疗慢性阻塞性肺疾病稳定期临床研究[J].新中医,2024,56(17):33-38

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  • 在线发布日期: 2024-09-11
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