Abstract： Objective： To observe the clinical effect of modified Shenling Baizhu San for growth retardation of preschool children. Methods：A total of 82 children with growth retardation were selected as the study subjects and divided into the observation group and the control group according to the random number table method， with 41 cases in each group. The control group was given conventional treatment such as nutrition supplementation and dietary guidance，and the observation group was additionally treated with modified Shenling Baizhu San based on the treatment of the control group. Clinical effects and adverse reactions were compared between the two groups. Changes in levels of serum zinc，hemoglobin，growth hormone，and insulin-like growth factor-1，as well as traditional Chinese medicine syndrome scores were compared between two groups before and after treatment. After a three-month follow-up， body mass was compared between two groups before and after treatment. Results： The total effective rate was 95.12% in the observation group， higher than that of 75.61% in the control group (P＜0.05). After treatment，traditional Chinese medicine syndrome scores in the two groups were declined (P＜0.05)，and the traditional Chinese medicine syndrome scores in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of serum zinc and hemoglobin in the two groups were increased (P＜0.05)， and the two levels in the observation group were higher than those in the control group (P＜0.05). After treatment，the levels of serum growth hormone，and insulin-like growth factor-1， as well as body mass in the two groups were increased (P＜0.05)， and the levels of serum growth hormone， and insulin-like growth factor-1， as well as body mass in the observation group were higher than those in the control group (P＜0.05). There was no significant difference being found in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： Modified Shenling Baizhu San has a definite curative effect in the treatment of growth retardation of preschool children. It can enhance clinical effects， regulate the expression of serum zinc and hemoglobin in the body， and improve serum growth hormone levels and appetite，which is safe and reliable.