Abstract：Objective：To observe the clinical effect of Tongfu Xiere Prescription and Dahuang Mangxiao Powder combined with conventional therapy on acute pancreatitis with liver-gallbladder damp-heat syndrome. Methods： A total of 98 cases of patients who had acute pancreatitis with liver-gallbladder damp-heat syndrome were enrolled in the study and randomly divided into the combination group and the western medicine group，with 49 cases in each group. The western medicine group received conventional therapy， and the combination group was additionally treated with the oral administration of Tongfu Xiere Prescription and the external application with Dahuang Mangxiao Powder at Shenque (RN8) point based on conventional therapy. Both groups were treated for seven days. The disappearance time of abdominal pain and distention，the time for body temperature to return to normal，and the recovery time of bowel sounds were observed in the two groups. Before treatment and after seven-day treatment， traditional Chinese medicine (TCM) syndrome scores were evaluated in the two groups and the levels of inflammatory factors [interleukin (IL) -6 and tumor necrosis factor-α (TNF-α)，and C-reactive protein (CRP)] and serum amylase (AMS) were measured. Clinical effects were compared between the two groups. Results：After treatment， the total effective rate in the combination group was higher than that in the western medicine group (P＜ 0.05). The disappearance time of abdominal pain and distention，the time for body temperature to return to normal， and the recovery time of bowel sounds in the combination group were shorter than those in the western medicine group (P＜0.05). The scores of abdominal distention and pain，sticky stool，yellow body and eyes，polydipsia，chest oppression，and dark urine with a low output in the two groups were declined when compared with those before treatment (P＜0.05)；the six TCM syndrome scores in the combination group were lower than those in the western medicine group (P＜0.05). The levels of TNF- α，IL-6，CRP， and AMS in the two groups were decreased when compared with those before treatment (P＜0.05)； the levels of TNF- α，IL-6，CRP，and AMS in the combination group were lower than those in the western medicine group (P＜0.05). Conclusion：Tongfu Xiere Prescription and Dahuang Mangxiao Powder combined with conventional therapy has a significant effect on the treatment of acute pancreatitis with livergallbladder damp-heat syndrome， which can enhance curative effects and better relieve symptoms and inflammatory reactions.