Abstract：Objective：To observe the clinical effect of Xingbei Zhike Granules and western medicine on cough variant asthma (CVA) with syndrome of external cold and internal heat. Methods：A total of 206 CVA patients were selected as study objects and divided into the treatment group and the control group according to the simple randomization method， with 103 cases in each group. Finally， 101 cases in the treatment group (excluding two cases) completed the trial； 100 cases in the control group (excluding two cases) completed the trial. The control group was treated with conventional symptomatic western medicine， and the treatment group was given Xingbei Zhike Granules and western medicine. After 14 days of treatment， the clinical effects， traditional Chinese medicine (TCM) syndrome scores， Leicester Cough Questionnaire (LCQ)， lung function [peak expiratory flow (PEF)， forced vital capacity (FVC)， forced expiratory volume in one second (FEV1)] and levels of serum inflammatory factors [interleukin-6 (IL-6)， tumor necrosis factor- α (TNF-α)] in the two groups were evaluated. Results：The total effective rate was 93.07% in the treatment group and 82.00% in the control group，the difference being significant (P＜0.05). After treatment，the TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the TCM syndrome scores in the treatment group were lower than those in the control group (P＜0.05). After treatment， the scores of psychological area， physiological area， social area and total scores of LCQ in the two groups were increased when compared with those before treatment (P＜0.05)，and the LCQ sub-scores above and the total score of LCQ in the treatment group were higher than those in the control group (P＜0.05). After treatment， the levels of PEF， FVC and FEV1 in the two groups were increased when compared with those before treatment (P＜0.05)，and the above three levels in the treatment group were higher than those in the control group (P＜0.05). After treatment，the levels of serum IL-6 and TNF-α in the two groups were decreased when compared with those before treatment (P＜ 0.05)， and the above two levels in the treatment group were lower than those in the control group (P＜ 0.05). Conclusion：The therapy of Xingbei Zhike Granules and western medicine has a definite therapeutic effect on the symptomatic treatment of CVA with syndrome of external cold and internal heat，which can relieve the clinical symptoms，improve lung function，inhibit the inflammatory responses of the body，and reduce the impact of cough on the quality of life of patients.