Abstract： Objective： To observe the clinical effect of the therapy of warming kidney and unblocking governor vessel acupuncture and moxibustion combined with repetitive transcranial magnetic stimulation (rTMS) on Parkinson's disease complicated with depression (PDD) and its effects on homocysteine (Hcy) and serum urine acid (UA). Methods： A total of 110 PDD patients were divided into the control group and the observation group according to the random number table method， with 55 cases in each group. In addition to routine antiparkinsonian medications，the control group was additionally treated with rTMS and the observation group with rTMS combined with warming kidney and unblocking governor vessel acupuncture and moxibustion. The two groups were treated for four weeks. The scores of Unified- Parkinson Disease Rating Scale (UPDRS) and Hamilton Depression Scale-17 items (HAMD-17)， levels of serum Hcy and UA before and after treatment as well as clinical effects were compared between the two groups. Results： After treatment， each score in UPDRS and the total scores in the two groups were decreased (P＜0.05)， and each score in UPDRS and the total score in the observation group were lower than those in the control group (P＜0.05). After one month of follow-up，each score in UPDRS and the total score in the observation group were lower than those before and after treatment and the control group at the same time (P＜0.05)，and each score in UPDRS and the total score in the observation group were lower than those in the control group (P＜0.05)； there was no significant difference being found in the comparisons of each score in UPDRS and the total score in the control group when compared with those after treatment (P＞0.05). After treatment， the HAMD-17 scores in the two groups were decreased (P＜ 0.05)，and the HAMD-17 score in the observation group was lower than that in the control group. After one month of follow-up， the HAMD-17 score in the observation group was lower than that before and after treatment and the control group at the same time (P＜0.05)，and there was no significant difference being found in the comparison of the HAMD-17 score in the control group when compared with that after treatment (P＞0.05). After treatment， the serum Hcy levels in the two groups were decreased (P＜0.05)， and the serum Hcy level in the observation group was lower than that in the control group (P＜0.05)； the serum UA levels were increased (P＜0.05)， and the serum UA level in the observation group was higher than that in the control group (P＜0.05). After one month of follow-up， the serum Hcy level in the observation group was lower than that before and after treatment and the control group at the same time (P＜0.05)，the serum UA level was higher than that before and after treatment and the control group at the same time (P＜0.05)，and there was no significant difference being found in the comparisons of the levels of Hcy and UA in the control group when respectively compared with those after treatment (P＞0.05). After treatment，the total effective rate was 92.73% in the observation group，higher than that of 81.82% in the control group (P＜0.05). Conclusion： The therapy of warming kidney and unblocking governor vessel acupuncture and moxibustion combined with rTMS can improve the motor symptoms of PDD patients and decrease the cerebral oxidative stress injuries and serum Hcy level， increase the UA level and effectively correct the depressed mood.