Abstract ： Objective ： To observe the clinical effect of Wenyang Xiaozheng Prescription on stage 3 chronic kidney disease of yang deficiency and blood stasis type. Methods： A total of 104 patients with stage 3 chronic kidney disease of yang deficiency and blood stasis type were randomly divided into the control group and the trial group according to the random number table method， with 52 cases in each group. The control group received general basic treatment，and the trial group received oral administration of Wenyang Xiaozheng Prescription based on the treatment of the control group. Both groups were treated for eight weeks. The traditional Chinese medicine syndrome scores，kidney function，24-hour proteinuria， blood albumin，and urinary transforming growth factor-β1 (TGF-β1) before and after treatment，as well as the clinical effects and incidence of adverse reactions were compared between the two groups. Results： The total effective rate was 67.31% in the trial group，higher than that of 32.69% in the control group (P＜ 0.05). After treatment， the traditional Chinese medicine syndrome scores in the two groups were decreased (P＜0.05)， and the score in the trial group was lower than that in the control group (P＜0.05). After treatment，urea nitrogen and blood creatinine in the two groups were decreased (P＜0.05)，and the indexes in the trial group were lower than those in the control group (P＜0.05). Glomerular filtration rate (GFR) in the two groups were increased (P＜0.05)，and the one in the trial group was higher than that in the control group (P＜0.05). After treatment， the blood albumin levels in the trial group were increased (P＜ 0.05)， and the level in the trial group was higher than that in the control group (P＜0.05). The levels of urinary TGF-β1 in the two groups were decreased (P＜0.05)，and the level in the trial group was lower than that in the control group (P＜0.05)；There was no significant difference of 24-hour proteinuria between the two groups before and after treatment (P＞0.05). No significant adverse reactions were observed in the two groups. Conclusion：Wenyang Xiaozheng Prescription has a definite clinical effect in treating stage 3 chronic kidney disease of yang deficiency and blood stasis type， which can improve the clinical symptoms， increase serum albumin，and reduce urinary TGF-β1，improve kidney function with high safety.