Clinical Study on Modified Fangfeng Xionggui Decoction Combined with Ebastine Tablets for Chronic Urticaria with Blood Deficiency and Wind-Dryness Syndrome
Abstract:Objective:To observe the clinical effect of modified Fangfeng Xionggui Decoction combined with Ebastine Tablets for chronic urticaria (CU) with blood deficiency and wind-dryness syndrome. Methods: A total of 76 cases of CU patients with blood deficiency and wind-dryness syndrome were selected and divided into the control group and the observation group according to the random number table method, with 38 cases in each group. The control group was treated with Ebastine Tablets, and the observation group was additionally treated with modified Fangfeng Xionggui Decoction based on the treatment of the control group. Both groups were treated for eight weeks. The clinical effects in the two groups were evaluated; symptom scores, Dermatology Quality of Life Index (DLQI) scores, levels of coagulation indexes of serum D-dimer (D-D) and fibrinogen degradation product (FDP) were compared between the two groups; the incidence of adverse reactions was counted. Results:The total effective rate was 97.37% in the observation group, higher than that of 78.95% in the control group (P<0.05). After treatment, symptom scores in the two groups were decreased when compared with those before treatment (P<0.05), and each symptom score in the observation group was lower than that in the control group (P<0.05). After four and eight weeks of treatment, DLQI scores in the two groups were gradually decreased (P< 0.05),and DLQI score in the observation group was lower than that in the control group at the same time point (P<0.05). After treatment,the levels of serum D-D and FDP in the two groups were decreased when compared with those before treatment (P<0.05),and the levels of serum D-D and FDP in the observation group were lower than those in the control group (P<0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Modified Fangfeng Xionggui Decoction combined with Ebastine Tablets has a good clinical effect in the treatment of CU patients with blood deficiency and wind-dryness syndrome, which can improve coagulation function and contribute to the improvement of symptoms,signs and quality of life of patients.