Abstract：Objective：To explore the mechanism of Huoluo Xiaoling Pillets in treating ischemic stroke by using network pharmacology methods. Methods： The active ingredients and effect targets of Huoluo Xiaoling Pillets were retrieved by using Symptom Mapping (SymMap)， Traditional Chinese Medicine Integrated Database (TCM-ID)，Herbal Ingredient and Target Database (HIT)，and Swiss Target Prediction database；the disease targets and differentially expressed genes in ischemic stroke were screened through databases such as Human Gene Database (GeneCards)， Comparative Toxicogenomics Database (CTD)， DisGeNET，and Gene Expression Omnibus (GEO)；the effect targets of Huoluo Xiaoling Pillets，differentially expressed genes， and disease targets of ischemic stroke were intersected by using UpSetR， and the targets related to the treatment of ischemic stroke with Huoluo Xiaoling Pillets were screened out； the enrichment analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed on relevant targets through the Metascape database. The protein-protein interaction networks and drug-active ingredient-target gene networks were constructed by Cytoscape 3.9.10 software，and the core components and targets of Huoluo Xiaoling Pillets for treating ischemic stroke were screened. The differences in immune cell infiltration between normal and ischemic samples in the GSE16561 dataset were analyzed through single sample gene set enrichment analysis，and the correlation between core targets and immune cell infiltration levels were analyzed. Molecular docking was applied to verify the affinity between the core targets and the active ingredients. Results： A total of 226 active ingredients of Huoluo Xiaoling Pillets were obtained， with 1 541 targets， 712 targets for ischemic stroke， and 3 136 differentially expressed genes. After taking the intersection，a total of 82 anti-ischemic stroke targets were obtained for Huoluo Xiaoling Pillets. GO enrichment analysis found that the targets of Huoluo Xiaoling Pillets in treating cerebral ischemic stroke mainly participated in biological processes such as inflammatory responses， lipopolysaccharide responses， positive regulation of cytokine production， hormone responses， and positive regulation of cell migration. KEGG analysis suggested that the mechanism of of Huoluo Xiaoling Pillets in treating ischemic stroke is related to the cancer pathway， phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt)，and interleukin (IL)-17 signaling pathway. The protein-protein interaction network and drug-active ingredient-target gene network yielded core targets such as C-C motif ligand 2 (CCL2)，IL-1β， and matrix metalloproteinase 9 (MMP9)， as well as 10 core components including quercetin， tanshinone IIA， resveratrol， curcumin， salvianolic acid， and ferulic acid. Pearson correlation analysis showed that IL-1β and MMP9 are correlated with immune cell infiltration levels such as neutrophils and endothelial cells. The molecular docking results showed that IL-1β and MMP9 bind stably with the core components of Huoluo Xiaoling Pillets. Conclusion： The active ingredients in Huoluo Xiaoling Pillets， such as quercetin， tanshinone IIA，resveratrol，curcumin，salvianolic acid，and ferulic acid，can act on core targets such as IL-1β and MMP9，and treat ischemic stroke by regulating the cancer pathway，and PI3K/Akt，and IL-17 signaling pathways.