Abstract: Objective: To observe the curative effect of Modified Taohong Siwu Decoction combined with conventional detumescence therapy for fracture swelling of foot and ankle. Methods : A total of 118 cases of patients with fracture swelling of foot and ankle of qi stagnation and blood stasis type were selected and divided into the treatment group and the control group according to the random number table method, with 59 cases in each group. The control group was treated with conventional detumescence therapy, and the treatment group was treated with Modified Taohong Siwu Decoction combined with conventional detumescence therapy. Both groups were treated continuously for seven days. The clinical effects and improvement of clinical symptoms were compared between the two groups. The changes in traditional Chinese medicine syndrome scores, swelling degree, pain degree [Visual Analogue Scale for Pain (VAS)],and hemorheological index values (whole blood viscosity,and plasma specific viscosity) were compared before and after treatment between the two groups. Results: The total effective rate was 98.31% in the treatment group, and 88.14% in the control group, the difference being significant (P< 0.05). After treatment, the traditional Chinese medicine syndrome scores, swelling degree, and VAS scores in the two groups were decreased when compared with those before treatment (P<0.05),and the values of the above three indicators in the treatment group were lower than those in the control group (P< 0.05). After treatment, the swelling reduction time and pain disappearance time in the treatment group were earlier than those in the control group (P<0.05),and the ankle dorsiflexion and ankle flexion degree were greater than those in the control group (P<0.05). After treatment,the values of whole blood viscosity and plasma viscosity in the two groups were decreased when compared with those before treatment (P< 0.05),and the values of whole blood viscosity and plasma viscosity in the treatment group were lower than those in the control group (P<0.05). Conclusion: Modified Taohong Siwu Decoction combined with conventional detumescence therapy for patients with fracture swelling of foot and ankle of qi stagnation and blood stasis type is beneficial for improving blood viscosity, promoting blood circulation recovery, alleviating clinical symptoms, reducing swelling and pain at the fracture site, shortening the time for swelling and pain improvement,and accelerating joint function recovery.