Abstract：Objective：To explore the prescription and medication rules of Chinese medicine for treating depression in Parkinson's disease based on Traditional Chinese Medicine Inheritance Support System. Methods：The databases of CNKI，VIP，and Wanfang were retrieved from the founding of the databases to February 2023 to collect relevant literature on the treatment of depression in Parkinson's disease with Chinese medicine， and analyze their medication rules using Traditional Chinese Medicine Inheritance Support System V2.5. Results： Finally， a total of 88 prescriptions were included， involving 133 Chinese medicinals. The high-frequency medicinals used to treat depression in Parkinson's disease include Paeoniae Radix Alba， Bupleuri Radix， Glycyrrhizae Radix et Rhizoma， Rehmanniae Radix Praeparata， Angelicae Sinensis Radix，and Gastrodiae Rhizoma. The four qi distribution of medicinals was mainly warm and cold. The five flavors were mainly sweet，bitter，and acrid. The main meridians were liver，spleen，and kidney. The combination of “Paeoniae Radix Alba-Bupleuri Radix”，“Glycyrrhizae Radix et Rhizoma -Paeoniae Radix Alba”， and “Rehmanniae Radix Praeparata-Paeoniae Radix Alba” were commonly used couplet medicines，and four new combinations were obtained through cluster analysis. Conclusion：Based on the principle of harmonizing yin and yang，Chinese medicine treating depression in Parkinson's disease mainly focuses on enriching and nourishing the liver and kidney， calming the liver and extinguishing wind， and rectifying qi to resolve constraint. According to the development of the disease，medication is used based on syndrome differentiation. The four new formulas obtained through data mining can provide ideas for clinical treatment of this disease.