Abstract：This paper introduces Professor MA Yunzhi's clinical experience in diagnosis and treatment of motor neuron disease. Professor MA believes that motor neuron disease is mainly caused by deficiency of congenital endowment and acquired loss of nutrition. The location of disease is in the muscles and sinews， related to the spleen，stomach，liver and kidney. The nature of disease is mainly deficiency syndrome and deficiency-excess complex is not uncommon as well. In diagnosing and treating motor neuron disease， Professor MA identifies the disease course and stage， disease location of zang-fu organs， deficiency in origin and excess in superficiality， severity of disease， as well as transmuted patterns of common syndromes to treat motor neuron disease based on syndrome differentiation from the aspects of dampheat， the spleen and stomach， the liver and kidney， and phlegm and stasis. The treatment methods include clearing and removing damp-heat，unblocking sinews and vessels，supplementing the spleen and boosting the stomach， transporting and lifting lucid yang， enriching and nourishing the liver and kidney， nourishing yin and clearing heat， warming and supplementing the spleen and kidney， strengthening sinews and bones，boosting qi and nourishing nutritive qi，and invigorating blood and dissolving stasis.