Abstract： Objective： To observe the application of Banxia Baizhu Tianma Decoction combined with Nicardipine in patients with hypertensive cerebral hemorrhage and its effect on serum D-dimer (D-D)， cystatin C (CysC). Methods：A total of 108 cases of patients with hypertensive cerebral hemorrhage were selected and divided into the control group and the trial group according to the random number table method，with 54 cases in each group. The control group was given the oral administration of Nicardipine， and the trial group was treated with Banxia Baizhu Tianma Decoction combined with Nicardipine. Both groups were treated for 14 days. Before and after treatment， the changes in blood pressure， intracranial hematoma， intracranial pressure， cerebral blood perfusion [regional cerebral blood flow (rCBF)， time to peak (TPP) and mean transit time (MTT)]，the levels of serum D-D and CysC，and the scores of Glasgow Coma Scale (GCS) and Activities of Daily Living (ADL) were compared between the two groups. Results： After 7 and 14 days of treatment，the levels of systolic pressure (SBP) and diastolic pressure (DBP) in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of SBP and DBP in the trial group were lower than those in the control group at the same time point (P＜0.05). After treatment，the intracranial hematoma volume and intracranial pressure in the two groups were decreased when compared with those before treatment (P＜0.05)， and the intracranial hematoma volume and intracranial pressure in the trial group were lower than those in the control group (P＜0.05). After treatment， rCBF levels in the two groups were increased when compared with those before treatment (P＜0.05)，and the length of TPP and MTT were decreased when compared with those before treatment (P＜0.05)； the rCBF level in the trial group was higher than that in the control group (P＜0.05)，and the length of TPP and MTT were lower than those in the control group (P＜0.05). After treatment，the levels of D-D and CysC in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of D-D and CysC in the trial group were lower than those in the control group (P＜0.05). After treatment，the scores of GCS and ADL in the two groups were increased when compared with those before treatment (P＜ 0.05)， and the above two scores in the trial group were higher than those in the control group (P＜0.05). Conclusion： Banxia Baizhu Tianma Decoction combined with Nicardipine for patients with hypertensive cerebral hemorrhage can effectively control blood pressure， promote intracranial hematoma absorption， improve coagulation function，CysC levels and cerebral blood perfusion，protect their nervous system and improve their self-care ability.