Abstract： Objective： To observe the clinical effect of the therapy of Yupingfeng Granules combined with Budesonide and Formoterol Fumarate Powder for Inhalation on bronchial asthma and its effects on the symptom control， lung function and orrhology indexes of patients. Methods： A total of 92 patients with bronchial asthma were included into the study and divided into the control group and the trial group according to the random number table method，with 46 cases in each group. The control group was given Budesonide and Formoterol Fumarate Powder for Inhalation for treatment， and the trial group was additionally treated with Yupingfeng Granules based on the treatment of the control group. After treatment， the clinical effects， incidence of adverse reactions， symptoms control [syndrome scores and scores of Asthma Control Test (ACT)]， and the levels of lung function indexes [forced expiratory volume in one second (FEV1)，peak expiratory flow (PEF) and breathing rate] and of orrhology indexes [vascular endothelial growth factor (VEGF)，S100 calcium binding protein A4 (S100A4) and eosinophil cationic protein (ECP)] were compared before and after treatment between the two groups. Results： After treatment， the total effective rate was 97.83% in the trial group，higher than that of 80.43% in the control group，the difference being significant (P＜0.05). After treatment， the syndrome scores of cough and gasp， expectoration， suppression in the chest，and wheezing rale in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above four scores in the trial group were lower than those in the control group (P＜0.05). After treatment，the ACT scores in the two groups were increased when compared with those before treatment (P＜0.05)， and the ACT score in the trial group was higher than that in the control group (P＜0.05). After treatment， the levels of FEV1 and PEF in the two groups were increased when compared with those before treatment (P＜0.05)， and the breathing rate was decreased when compared with that before treatment (P＜0.05)； the levels of FEV1 and PEF in the trial group were higher than those in the control group (P＜0.05)，and the breathing rate was lower than that in the control group (P＜0.05). After treatment，the levels of serum VEGF，S100A4 and ECP in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above three levels in the trial group were lower than those in the control group (P＜0.05). During treatment，the incidence of adverse reactions was 10.87% in the trial group and 6.52% in the control group，there being no significance in the difference (P＞ 0.05). Conclusion： The therapy of Yupingfeng Granules combined with Budesonide and Formoterol Fumarate Powder for Inhalation has a definite curative effect on bronchial asthma， which can effectively control the clinical symptoms and improve the lung function， and its mechanism may be related to the down-regulation of levels of serum VEGF，S100A4 and ECP.