Abstract： Objective： To observe the curative effect of five-phase virtual reality (VR) technology combined with cognitive-behavioral therapy for insomnia (CBT-I) for chronic insomnia with syndrome of non-interaction between the heart and the kidney. Methods： A total of 60 cases of patients with chronic insomnia with syndrome of non-interaction between the heart and the kidney were selected and divided into the trial group and the control group according to the random number table method，with 30 cases in each group. The control group was treated with CBT-I， and the trial group was additionally treated with five-phases VR technology based on the treatment of the control group. Both groups were treated for four weeks. The clinical effects were compared between the two groups. The changes in low-frequency power (LF)，high-frequency power (HF)，ratio of low-frequency power to high-frequency power (LF/HF)， Pittsburgh Sleep Quality Index (PSQI)， traditional Chinese medicine (TCM) syndrome scores， Hamilton Depression Scale-17 (HAMD-17)， and Hamilton Anxiety Scale (HAMA) index values were compared before and after treatment. Results： The total effective rate was 66.67% in the trial group and 16.67% in the control group，the difference being significant (P＜0.05). After four weeks of treatment，the LF index values in the trial group，and the LF/HF index values in the trial group and the control group were compared before and after treatment， the difference being significant (P＜0.05). After treatment， the LF and LF/HF index values in the trial group were lower than those in the control group (P＜0.05). After foru weeks of treatment，the scores of sleep quality，sleep onset time，sleep efficiency，hypnotic drugs，and daytime dysfunction，and the total score in the trial group were lower than those in the control group (P＜0.05). After four weeks of treatment， the TCM syndrome scores， HAMA scores， and HAMD-17 scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the TCM syndrome scores，HAMA score，and HAMD-17 score in the trial group were lower than those in the control group (P＜0.05). Conclusion：The five-phase VR technology combined with CBT-I has a good curative effect on chronic insomnia with syndrome of non-interaction between the heart and the kidney，which can improve the parasympathetic nervous system and balance in the autonomic nervous system，and enhance the sleep quality.